Studies on Pyrimidine Derivatives and Related Compounds. XLIX. Several Reactions of 1-[(2-Methyl-4-amino-5-pyrimidinyl) methyl]-3-alkyl-4-(2-hydroxyethyl)-5-methyl-imidazolium Salts.
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چکیده
منابع مشابه
Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors.
permits easy passage across the blood-brain barrier. Others have argued that since brain tumors do not possess a blood brain barrier, the lipid solubility of the nitrosoureas can play no robein their therapeutic effectiveness. We have tested ACNU, a water-soluble nitrosourea, for its chemotherapeutic effect in several animal brain tumor models and have compared ACNU to other more lipid-soluble ...
متن کاملEffect of 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-342-chloroethyl}. 3-nitrosourea Hydrochloride on Experimental Brain Tumors'
permits easy passage across the blood-brain barrier. Others have argued that since brain tumors do not possess a blood brain barrier, the lipid solubility of the nitrosoureas can play no robein their therapeutic effectiveness. We have tested ACNU, a water-soluble nitrosourea, for its chemotherapeutic effect in several animal brain tumor models and have compared ACNU to other more lipid-soluble ...
متن کاملMethyl 4-(4-fluorophenyl)-6-isopropyl-2-[N-methyl-N-(methylsulfonyl)amino]pyrimidine-5-carboxylate
In the mol-ecule of the title compound, C(17)H(20)FN(3)O(4)S, the pyrimidine and benzene rings are oriented at a dihedral angle of 35.59 (3)°. Intra-molecular C-H⋯N and C-H⋯O hydrogen bonds result in the formation of one five- and two six-membered non-planar rings. One of the six-membered rings adopts a chair conformation, while the other six-membered ring and the five-membered ring exhibit env...
متن کامل5 - Amino - 3 - methyl - 1 , 2 , 4 - thiadiazole
An improved procedure for isolation of 5-amino-3-methyl-1,2,4-thiadiazole in pure form on a multi-gram scale without chromatography is reported. Its 1H and 13C-NMR and IR data are presented and previously published erroneous data corrected. The molecular structure is confirmed by X-ray diffraction which shows layers consisting of an elaborate two-dimensional hydrogen bonded network of molecules.
متن کاملThe Crystallographic, Spectroscopic and Theoretical Studies on (E)-2-[((4-fluorophenyl)imino)methyl]-4-nitrophenol and (E)-2-[((3-fluorophenyl)imino)methyl]-4-nitrophenol Compounds
In this study, two new salicylideneaniline derivative compounds which are an isomer of each other have been synthesized and characterized by X-Ray Diffraction (XRD) technique, IR spectroscopy, and theoretical method. While (E)-4-(dihydroxyamino)-2-(((4-fluorophenyl)imino) methyl)phenol (1), crystalizes triclinic P-1 space group, (E)-4-(dihydroxyamino)-2-(((3-fluorophenyl)im...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1967
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.15.1294